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  • Promising Stem Cell Research for Celiac Disease

SILVER SPRING, Md., Mar 05, 2012 (BUSINESS WIRE) -- Nuvilex, Inc. (otcqb:NVLX), an emerging biotechnology provider of cell and gene therapy solutions, released information today about the company's cell encapsulation technology and the breakthrough in stem cell research which overcomes specific fundamental challenges faced in stem cell therapy--host rejection and migration of implanted cells away from the target site.

Stem cell therapy is believed by many medical researchers as holding a key to treating cancer, Type 1 diabetes mellitus, Parkinson's disease, Huntington's disease, Celiac Disease, cardiac failure, muscle damage, neurological disorders, and other chronic, debilitating diseases. There are presently >1,400 registered trials using stem cells that are recruiting patients (ClinicalTrials.gov). The encapsulation technology being advanced allows live stem cells to be implanted into robust, flexible and permeable capsules where they can replicate inside the capsules at the target site free from attack by the body's immune system and free to undergo natural changes to become the appropriate cell type needed.   more...       

  • Low Adherence to biopsy guidelines affects Celiac Disease diagnosis in the US:

July 7, 2011 - A new study has found that most patients undergoing biopsy of the small intestine do not have the recommended number of samples to diagnose celiac disease. The study, published in the July 2011 issue of Gastrointestinal Endoscopy, analyzed a national database of biopsy specimens maintained by Caris Life Sciences (Irving, TX). More than 100,000 patients had a biopsy of the small intestine, but only 35 percent of them had at least four samples taken, the number recommended by professional guidelines. Celiac disease is common, affecting approximately 1 percent of the population in the United States. However, the vast majority of patients with celiac disease in the United States have not been diagnosed. Many of these patients seek health care for symptoms including diarrhea, weight loss, or fatigue due to anemia. The diagnosis of celiac disease is made by biopsy of the small intestine, but factors related to the performance of biopsy may contribute to the under-diagnosis of celiac disease in the United States.  More
  • How Celiac Disease is Diagnosed:
Symptoms: View the systems in the column to the right.  These are the early indicators that you might need to see a physician for further diagnosis.  Most common symptoms are intermittent diarrhea, abdominal pain, and bloating.  But the symptoms can include other indicators ranging from irritability and weakness to dental and bone disorders.

Medical Diagnosis Process:  When a physician begins testing you for celiac disease, he or she will usual follow a procedure like you see below:
  • As celiac disease can be hereditary, you will be asked for a thorough medical history;
  • You will next be questioned about your symptoms;
  • There will be blood tests ordered that help identify celiac disease.  Tests to measure albumin levels, alkaline phosphatase levels, clotting factor abnormalities, cholesterol, blood counts, liver enzymes, and prothrombin time are the usual first steps.  
  • If the blood work comes back positive, the physician will then usually order antibody tests.
  • If the antibody tests indicate the presence of celiac disease, the next step is an upper endoscopy is performed to biopsy a piece of tissue from the duodenum - the first part of the small intestine.  The biopsy will show the condition of the villi - the hair-like structures that line the intestine - and their ability to absorb nutrients.
When Celiac Disease is Discovered:  The usual next step is that you will be advised to follow a gluten-free diet.  More and more products are finding their way onto the shelves of your local supermarket, and we also provide a comprehensive list of 5,000 plus items that can be ordered through our gluten-free superstore.  This list is a special search of foods available through Amazon.  When you order, you will be dealing with Amazon and the companies who will ship the products.  This is a service to our readers to make it easier to get started.  

Unsafe foods and ingredients: We have a webpage on this site that lists all of the unsafe foods and ingredients that have been discovered.  While avoidance of these foods is critical, you must be sure that you are getting these items from a certified gluten-free source or restaurant, as cross-contamination is a problem in preparation.

Other Resources:  As you will discover on this page, we provide you with videos, medical data, and breaking news.  You can follow me on Twitter where I put a lot of information.  We even have most all of the books on Celiac Disease and Gluten-Free topics in our gluten-free superstore, which uses Amazon to identify these items.
  • Celiac Disease Linked to Earlier Menopause
June 17, 2011 - According to an article in Reuters Health, women with untreated celiac disease may hit menopause earlier in life, as well as have a higher risk of pregnancy complications, when a study compared that group to a group without celiac disease.  The study went on to note that if celiac disease was diagnosed and treated early, that the onset of menopause would not be premature.  More...
  • Celiac Disease Vaccine on the Way

    May 13, 2011 4:26 PM EDT - People who suffer from celiac disease may have something to celebrate if scientific trials from Australia come to fruition. The scientists have just successfully completed the first stage tests for a vaccine.

    Scientists at Melbourne Austrailia''s Walter and Eliza Hall Institute say that their vaccine would "switch off" the immune reaction to gluten, which may mean that people who suffer from celiac disease would not have to eliminate gluten from their diets.

    "The gluten free diet is very difficult, it's costly, it's complex," said Dr. Jason Tye-Din. "Unfortunately even people who follow it very well - there's a large proportion who still don't get full healing of their bowel, so alternatives to the gluten free diet are really needed at the moment."

    The only bad news is that even if further trials are successful, estimates say the vaccine will not be available any earlier than 2017.

  • SUNDAY, May 8 (HealthDay News) -- Celiac disease is more common among children born in the spring and summer months, according to a new study from the Massachusetts General Hospital for Children.

    The findings suggest that the higher incidence of this autoimmune disease may be related to a combination of seasonal and environmental factors.  More...


  • Children with type 1 diabetes should be tested for thyroid disease and celiac disease at the time of their diabetes diagnosis, according to a new study reported on by Reuters Health. 
According to this study a third of children with type 1 diabetes have signs of other immune system disorders when they get diagnosed with diabetes.  More...
  • Celiac Disease Resolution Passes on Senate Floor
Senate Concurrent Resolution (SCR 7) from Senator Bob Huff (R-Diamond Bar) passed out of the Senate during a recent Floor vote and is now headed for the State Assembly. The measure seeks to raise awareness about a disease that affects three million people in America, by designating the month of May, 2011 as Celiac Disease Awareness Month in California. More...
  • 95% of Americans with Celiac Disease go Undiagnosed

    Approximately 95 percent of Americans with the disease go undiagnosed.  Through a sponsorship by B&G Foods, owner of Cream of Rice, this grant will support and further the Celiac Disease Foundation’s pursuit to provide a greater understanding of Celiac disease, gluten sensitivity, dietary compliance, future therapies, associated conditions and also the effect on family members. More...
  • Study Shows Immune Imbalance May Cause Celiac Disease

With increased levels of Interleukin 15, a compound responsible for the maintenance of cellular immune responses, development of celiac disease is more probable, according to a new study published in the journal Nature.

Celiac disease is caused by an aberrant immune response to the protein gluten. The immune response is probably due to the imbalance of compounds like Interleukin 15, the study suggested. By blocking an inflammatory protein called interleukin-15 (IL-15), doctors may be able to treat and prevent symptoms of celiac disease in some people, according to the new study.  More...


  • New Study: Accutane May Worsen Celiac Disease
  • Retinoic acid, a byproduct of vitamin A found in the former acne drug Accutane, may aggravate the symptoms of celiac disease, according to Julie Steenhuysen of Reuters.  More...

    • Mouse Study Suggests New Clues to Celiac Disease

      Retinoic acid might spur digestive disorder in those with genetic susceptibility

      WEDNESDAY, Feb. 9 (HealthDay News) -- A key discovery into how celiac disease develops may pave the way toward preventing this painful digestive disorder in those most at risk, a new animal study suggests.

      Using mice, scientists at the University of Chicago have identified a biochemical interaction that may trigger an autoimmune reaction in the intestines of genetically susceptible people.

      Specifically, the researchers found that retinoic acid, a form of vitamin A, seems to work together with high levels of a pro-inflammatory substance known as interleukin-15 (IL-15) to break the body's tolerance to gluten, a protein found in wheat, barley and rye.

      "This is the first time that we actually show how inducing a specific dysregulation in the intestines can lead to losing tolerance to a food antigen, and in particular to gluten," said study author Dr. Bana Jabri, co-director of the university's Digestive Disease Research Core Center.

      The finding is important, she added, "because we may now have a way to reintroduce tolerance to gluten since we know what to target." It should be noted that promising research done with animals often fails to produce beneficial results for humans. More...


    • Celiac disease patients prone to fractures - Mumbai. 
      In research conducted by the endocrinology department of BYL Nair Hospital, people with both celiac disease and type 1 diabetes have been found to have poor bone mineral density, making them susceptible to fractures.  More...
    • Canadian beer brewers are very concerned over the relabeling required by new laws.  At the root of the problem is the cost of replacing the bottles they've been recycling for decades.  Celiac disease is a driving force for the change.  More...
    • Celiac disease gets more awareness internationally.  For many people all around the world, no matter what socio-economic background or what age group they belong to, Celiac disease is a life challenge.

      An autoimmune disease, it produces an intolerance of foods that contain gluten, a protein found in wheat, and other grains such as barley, rye, and triticale. It causes an immune reaction in the small intestine that damages the lining and lowers the absorption levels of nutrients. This, in turn, leads to nutritional deficiencies.

      Read more:  Link to MedIndia
    • Celiac, Crohn's Disease Share Common Genetic Links

      Scientists Key in on Genetic Variants That Cause Inflammation in the Gut -

      Jan. 27, 2011 -- An international team of researchers has identified four genetic variants common to celiac disease and Crohn’s disease.

      The research may help to explain why people who have celiac disease appear to have a higher rate of Crohn’s disease than the general population. It may one day lead to new treatments that address the underlying inflammation involved in both conditions. More...

    • Safety for Patients With Celiac Disease of Baked Goods Made of Wheat Flour Hydrolyzed During Food Processing

      Martina D'Aniellolow asterisk, Maria Magliolow asterisk, Riccardo Tronconelow asterisk and Salvatore Auricchiolow asterisk

      Department of Plant Protection and Applied Microbiology, University of Bari, Bari, Italy

      low asterisk Department of Pediatrics and European Laboratory for the Study of Food Induced Diseases, University of Naples, Federico II, Naples


      Available online 15 October 2010.

      Background & Aims:

      Celiac disease (CD) is characterized by an inflammatory response to wheat gluten and rye and barley proteins. Fermentation of wheat flour with sourdough lactobacilli and fungal proteases decreases the concentration of gluten. We evaluated the safety of daily administration of baked goods made from this hydrolyzed form of wheat flour to patients with CD.

      Methods:

      Patients were randomly assigned to consumption of 200 g per day of natural flour baked goods (NFBG) (80,127 ppm gluten; n = 6), extensively hydrolyzed flour baked goods (S1BG) (2,480 ppm residual gluten; n = 2), or fully hydrolyzed baked goods (S2BG) (8 ppm residual gluten; n = 5) for 60 days.

      Results:

      Two of the 6 patients who consumed NFBG discontinued the challenge because of symptoms; all had increased levels of anti–tissue transglutaminase (tTG) antibodies and small bowel deterioration. The 2 patients who ate the S1BG goods had no clinical complaints but developed subtotal atrophy. The 5 patients who ate the S2BG had no clinical complaints; their levels of anti-tTG antibodies did not increase, and their Marsh grades of small intestinal mucosa did not change.

      Conclusions:

      A 60-day diet of baked goods made from hydrolyzed wheat flour, manufactured with sourdough lactobacilli and fungal proteases, was not toxic to patients with CD. A combined analysis of serologic, morphometric, and immunohistochemical parameters is the most accurate method to assess new therapies for this disorder.   To read more on this AGA Institute research.

    • University of Maryland School of Medicine receives $45 million from grateful patient -

      The family of a grateful patient has donated $45 million to the University of Maryland School of Medicine.

      The gift, which is the largest private donation in the University of Maryland system's history, came from Indiana couple Ken and Sheila Cafferty.

      "For years, my wife struggled with severe symptoms, with no diagnosis and no treatment for her condition," explained Ken Cafferty, a businessman from Carmel, Indiana, who is making the gift with his wife, Shelia, a registered nurse. "I endured this struggle with her, until Dr. Fasano and his staff at the Center for Celiac Research finally found answers for us, diagnosing Shelia with gluten sensitivity. We are making this gift with the hope that this new enterprise will help provide answers for other families in the same position, and hopefully make strides toward a cure to provide permanent relief for patients like Shelia."

      The university will use the money to establish the nation's only major research facility dedicated to the study of autoimmune and inflammatory diseases such as celiac disease, an intestinal disorder that interferes with absorption of nutrients from food, particularly gluten. The center will also focus on multiple sclerosis, chronic obstructive pulmonary disease, asthma and Type 1 diabetes.  More, click below:

      http://www.thedailytell.com/2010/10/university-of-maryland-school-of-medicine-receives-45-million-from-grateful-patient/

    • FDA Approves Two More Celiac Detection Tests.

      Portage-based Phadia announced Wednesday that it has received clearance from the United States Food and Drug Administration for two new autoimmune antibody assays.

      The new assays will provide physicians with additional tools needed to aid in the diagnosis of Celiac disease.

      The newly available assays, EliA GliadinDP IgA and EliA GliadinDP IgG (deamidated peptides), have proven to be essential, sensitive and specific markers to aid in the diagnosis of celiac disease.

      More info: Story
    • Active scleroderma is common in celiac patients.

      Scleroderma is a chronic, systemic autoimmune disease characterized by tissue fibrosis, or hardening, vascular changes, and auto-antibodies.   There are two forms of scleroderma.  More…

    • As many as 75% of overweight and obese people in the U.S. may be addicted through poor eating habits to either carbohydrates or the protein called gluten, which is found in all wheat, rye, barley and oat products. http://weight.insulitelabs.com/Addiction.php
    • Probiotics contain helpful bacteria that can potentially help celiac disease patients.  Prebiotics support probiotics. Probiotics are most commonly found in yogurt, tempeh, miso, and some milk and soy products. Prebiotics are nondigestible food fibers found in root vegetables, wheat, onions, garlic, and bananas, among other foods, and they serve to nourish probiotics. These natural substances may someday soon be proven to help people who have celiac disease.  We also sell probiotics in our Gluten Free Superstore.
    • Larazotide Acetate has shown to prevent some of the damage to the small intestine gluten causes.A University of Alberta doctor has helped to develop the drug and is overseeing the medical trials. So far, the first of three trials has shown some promising results.
    • "Fifty per cent of them had significant damage and only 15 per cent on the Larazotide," said Dr. R. Fedorak. http://viigo.im/2Ewa

    • Dear Joe DiDonato:  FDA is working on gluten labeling.  It will publish on our web site when it is final. 

      Ms. Jeannine Ertter, ASCP (HT)
      Public Affairs and Information Specialist
      Communication and Coordination Staff
      Division of Communication and Education
      Office of Food Defense and Emergency Response
      Center for Food Safety and Applied Nutriton
      U.S. - Food and Drug Administration

      ---------------------

      From: Joe DiDonato [mailto:joe_didonato@verizon.net]
      Sent: Tuesday, January 05, 2010 12:06 PM
      To: CFSAN-OCO2
      Cc: tatiana@thegfreview.com
      Subject: How do we petition the FDA for new warning labeling?

      We would like to formally petition the FDA for a warning label on foods that contain gluten.  Our group’s primary health problems include celiac disease and gluten intolerance.  1 in 133 people have celiac disease, and 30% of the population suffers from gluten intolerance.  The culprit is gluten, or more technically, the gliadin protein included in gluten which has been bioengineered into wheat.  There is 90% more gluten in our wheat than there was 100 years ago, and there are about 100 patents for gluten in our patent office.  The health risk posed to sufferers of gluten intolerance is sizeable, including the risk of celiac disease, osteoporosis, and other maladies.

      How do we go about a formal petition?  Are there any guidance manuals?

      Warm regards,

      Joe DiDonato

    • The strong link between what we eat and our brain is proven in this study of children with Autism.  RESULTS: In autistic syndromes, we can show marked increases in UV 215-absorbing material eluting after hippuric acid that are mostly peptides. We also show highly significant decreases after introducing a gluten- and casein-free diet with a duration of more than 1 year. We refer to previously published studies showing improvement in children on this diet who were followed for 4 years and a pairwise matched, randomly assigned study with highly significant changes. Click Here

    • WebMD reports that gluten-free camps help kids with celiac disease, based on University of California San Francisco.  To read more about this study, go to http://www.webmd.com/digestive-disorders/celiac-disease/news/20100212/gluten-free-camp-helps-celiac-disease-kids?src=RSS_PUBLIC

    • The NY Times reported it took Donna Sawka 30 years to be diagnosed with celiac disease.  Although this sounds extreme, this article goes on to report that the average diagnosis time is 10 years for most people with celiac disease: http://health.nytimes.com/ref/health/healthguide/esn-celiac-ess

    • Children who experience migraine headaches have a greater risk of being diagnosed with celiac disease.  In this informative article by neurologist David Perlmutter, several anecdotal and research based studies show an increased connection between gluten, celiac disease, and migraine headaches: http://www.renegadeneurologist.com/migraine-and-celiac-disease/

    • Rod-shaped Bacteria in Proximal Small Intestine Tied to Celiac Disease in Children - Research indicates that rod-shaped bacteria, of the species Clostridium, Prevotella, and Actinomyces, in the proximal small intestine may contribute to some cases of celiac disease in children. http://bit.ly/aywc9r

    • Taking antidepressants?  Your mood may be linked to the gluten in your diet.  Here's some interesting conversations between people who talk about the link between gluten, mood, and depression.  http://www.celiac.com/gluten-free/index.php?showtopic=34856&st=15&p=344695&#entry344695

    • Many doctors are beginning to see that corn can be a severe problem for the majority of gluten intolerant patients. Corn is a grain.  Corn has gluten.  Many believe that corn gluten does not induce damage the same way that wheat, barley, and rye do.  The fact of the matter is, gluten has not been studied adequately.  Most of what we know about celiac disease and gluten have to do with gliadin (the gluten found in wheat only). More: http://towncenterwellness.com/announcements/corn-gluten-damages-those-with-gluten-sensitivity/

    • Can you get "second-hand" gluten from eating animals bred on feed that contains gluten?  Most likely not, as the grain that is fed to the animals does not transfer proteins into the muscle. The proteins are broken down in the stomach to make energy for the animal to survive on, but they do not pass into the blood or muscle to cause any alarm to us. If you are having trouble with meat, it imight be a non-celiac related problem.  http://www.celiac.com/gluten-free/index.php?s=4241a8f9b076e2d3abde324a2aebde38&showtopic=7773

    • Although there is no cure for alopecia areata, research reports showed that patients with alopecia and celiac disease reported that their hair grew back after they adopted a gluten-free diet. Even in people without celiac disease, however, the course of alopecia is very unpredictable, and sometimes the hair simply grows back by itself.  http://celiacdisease.about.com/od/symptomsofceliacdisease/a/Alopecia.htm

    • Heartburn, or acid reflux, are digestive problems caused by gluten intolerance and allergies.  If you want to read more on this, here is a good discussion by people who have dealt with this problem.  http://www.peoplespharmacy.com/2009/02/27/glutenfree-diet/

    • Anxiety attacks may be related to the gluten in your diet.  Here's a very good discussion from people who suffer anxiety attacks and have fought their way back with a gluten-free diet: http://www.celiac.com/gluten-free/lofiversion/index.php/t18767.html

    • A fact that is known, but not well studied, is that celiac disease patients do not produce adequate protective antibody levels after receiving the hepatitis B virus (HBV) vaccine.  More: http://www.empowher.com/news/herarticle/2010/01/20/reduced-response-hepatitis-b-virus-vaccine-celiac-disease-patients

    • There is a connection between gluten and acne that is oftentimes overlooked.  Gluten contributes to acne in two ways. First, it causes damage to the small intestine, which could lead to nutritional deficiencies and an increased toxic body load (through leaky gut syndrome). The second link between gluten and acne is inflammation: http://www.naturalnews.com/024669_gluten_acne_health.html

    • The link between gluten, dairy, and ADHD was tested in a long-term study of 23 families.  22 of the 23 families placed their children on a strict gluten-free and/or milk-free diets.  22 of the 23 families reported clear improvements in their child's behaviour and attention-span.  http://www.celiac.com/articles/21800/1/ADHD-Caused-by-Digestive-Disorder/Page1.html

    • A Male CD person has a greater risk of infertility and other reproductive disturbances, as well as a greater incidence of hypoandrogenism. This medical condition means a deficiency of androgens in the body that leads to a lack of virility and sexual potency. http://bit.ly/5rhS50

    • Gluten lurks in a number of processed foods, including:
      • Salad dressings
      • Cold cuts
      • Egg substitutes
      • Beer
      • Instant flavored rice mixes
      • Flavored potato chips
      • Imitation crab (surimi)
      • Some herbal teas
      • Licorice and some chocolates

     

    • How to create an exclusion diet using "lamb and pears" to 'reset' your body.  Lamb and pears may appear to be a strange combination, but the reason they are chosen as part of a food allergy diet is because they are rarely indicated in allergies and are therefore relatively safe foods for most people with a food allergy to eat. Here's how it works: Lamb & Pears Exclusion Diet.  (Note: If you need a food diary, you can go to my "Unsafe Foods" tab and download a free one that I've provided.)

    • Gluten, Celiac Disease, and the Brain.  Many have asked how gluten enters the blood stream and crosses into the brain to potentially cause behavior change.  There are more studies needed, but here is one of the better articles on the subject: Gluten, Celiac Disease and the Brain.

    • Ever get angry and not seem to know why?  This is potentially one of the side effects of gluten.  Here's a forum on the topic so that you can see what others are saying about gluten and anger: Gluten and Anger Forum.

    • (See my previous Tweets below for statistical references.)  There is 90% more gluten in our wheat than there was a century ago; there are over 100 patents for gluten in our patent offices; and between celiac disease and the 30% of the population with gluten intolerance problems, millions are suffering.  We need to stop what we're doing to our food, and in the interim, press the FDA for a warning label on our food.  It seems to me that there is no difference between this health risk and the health risk that smoking and other allergens present. 

    • Seitan is all the rage in vegan kitchens for its versatility and uncanny meatishness, but the bad news for some is that it's made of wheat gluten. For more info: Seitan

    • "Could Gluten Sensitivity Be Causing Your Hair Loss?"  In this interesting article, Kristen Campbell talks about her personal experiences as well as interviews three other individuals to get their perspectives:    http://bit.ly/5CvQTw

    • After the digestive tract, the most commonly affected system to be affected by gluten is the nervous system. Anxiety, chemical imbalance, and depression can all be symptoms of gluten sensitivity. http://www.celiac.com/articles/21758/1/Gluten-Sensitivity-and-Depression/Page1.html

    • What is the Endomysial Antibody Test? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1379574/

    • In the landmark prevalence study on celiac disease by the University of Maryland, investigators determined that 60% of children and 41% of adults diagnosed during the study were asymptomatic (without any symptoms). During the prevalence study, researchers found that 21% of patients with a positive anti-endomysial antibody test could not receive a biopsy due to the refusal of their physician to perform the procedure or the insurance company to pay for it. http://www.uchicagokidshospital.org/pdf/uch_007937.pdf

    • Women with infertility test 10x higher for celiac disease than the normal population. And of pregnant women with celiac disease, 21% of women experienced pregnancy loss, and 16% of women experienced fetal growth restriction when they did not maintain a gluten free diet . http://bit.ly/WPrx7

    • While only 1 in 133 have celiac disease, some researchers say that gluten sensitivity may affect 30% of the population. While antibodies to the gluten protein gliadin were found in only 12% of the population using blood exams to diagnose gluten sensitivity, that percentage increases to 30% when  stool samples were examined for the antibodies: https://www.enterolab.com/StaticPages/Frame_Faq.htm#What_is

    • If you have a digestive disorder, you have a 1 in 56 chance of having celiac disease, according to Dr. Shari Lieberman and Linda Segall in their book The Gluten Connection.

    • The LA Times: New hope for celiac sufferers. Article covers the enzyme immunotherapy therapies in clinical trial: http://www.latimes.com/features/health/la-he-celiac21-2009dec21,0,5395819.story

    • There are over 100 patents for gluten in the US Patent Office, according to Dr. Shari Lieberman and Linda Segall in their book The Gluten Connection.

    • According to a New York Times article it takes the average patient with celiac disease 10 years to receive a diagnosis - and they're the lucky ones: http://health.nytimes.com/ref/health/healthguide/esn-celiac-ess

    • Fatigue, night blindness, back pain, and mouth sores are some of the lesser known symptoms of celiac disease.  For a complete list, see the Mayo Clinic article to the left, or this link from the Celiac Sprue Association: http://www.csaceliacs.org/celiac_symptoms.php

    • Angry, quick-tempered, impatient?  Here's one woman's comments about herself before she went gluten-free: "You are not alone. I am not a nice person to be around when I'm on gluten. Not so much now but in the early stages of healing and years before gluten-free I would get very angry, depressed and impatient. I'm by nature a VERY calm, patient person. Off gluten, I can't even "go there" if I try."  To find more: http://www.celiac.com/gluten-free/index.php?showtopic=34917

    • How to Test For Celiac Disease*:

    • Step 1:  Best initial screening test is a blood test:

                IgA Tissue Transglutaminase Antibody (IgA TTG)
                              - If positive then -

              Step 2:  Small Intestinal Mucosal Biopsy
                           - If positive then -

              Step 3:  Gluten Free Diet

                      *(see video at left at marker 00:22:00)

    • Mayo Clinic researchers have uncovered a link between celiac disease, a digestive condition triggered by consumption of gluten, and dementia or other forms of cognitive decline. http://www.sciencedaily.com/releases/2006/10/061010022602.htm

    • Excerpt quoted from The Gluten Connection by Dr Shari Lieberman: It is estimated that today’s wheat contains nearly 90 percent more gluten than wheat did from a century ago: http://bit.ly/5usjsY

    • The genetic predisposition of the disease is such that having a first degree relative with CD increases your odds of having CD to 1 out of 22, and a second degree relative to 1 in 39.

    • Celiac disease can wreak havoc on your body and even predispose you to liver disease or cancer.  Here's a good discussion from the Dr. Oz show: http://www.doctoroz.com/videos/celiac-disease-advantages-gluten-free-diet

    • The link between gluten and anxiety.  Conclusion: gluten-free diet helps diminish anxiety.  Here is a good discussion from people who have suffered anxiety and then improved substantially after a gluten free diet:  http://gluten-free-eaters.tribe.net/thread/4aee73b4-ba0e-4662-9cc8-7e50b35e9c57

    • The link between gluten and obesity.  Going on a gluten-free diet may significantly decrease hunger and weight.  Here's a compelling article written by a woman who researched the issue thoroughly, and then described her experience as she went gluten-free: http://www.celiac.com/articles/1033/1/Celiac-Disease-and-ObesityThere-is-a-Connection-by-Melissa-Croda-q/Page1.html

    • "Sorry, you've got fibromyalgia or you've got chronic fatigue syndrome, there's nothing we can do for you." Wrong!  Symptoms of gluten sensitivity and celiac disease include fatigue, headaches, joint pain, depression, irritability and gastro-intestinal irregularities. As a result, they're often mistaken for other serious disorders, including irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome.

    • Anxiety attacks?  It may not be "in your head."  More likely, it's the gluten in your diet.  Here's a very good discussion from people who suffer anxiety attacks and have fought their way back with a gluten-free diet: http://www.celiac.com/gluten-free/lofiversion/index.php/t18767.html

    • Some people who have been diagnosed with systemic lupus erythematosus (SLE) may really be suffering from an intolerance to the gluten in their diet, reports the Annals of the Rheumatic Diseases (2004;63:1501–3). http://bastyrcenter.org/content/view/703/

    • As celiac disease is hereditary, family members of a person with the disease may wish to be tested. Four to 12 percent of an affected person’s first-degree relatives will also have the disease.

    • Arcadia has received a Small Business Technology Transfer Program (STTR) grant from the National Institutes of Health in partnership with Washington State University (WSU) to research novel lines of wheat with reduced celiac disease-causing proteins. The grant was the first step in the company’s effort to identify and develop wheat varieties that can significantly expand the dietary options for people on gluten-free diets. Working with Dr. von Wettstein and his colleagues at WSU, Arcadia will use TILLING® technology to identify wheat plants in which harmful gluten proteins are minimized.  (Also see mention of how we bred gluten into wheat in video to left at 01:16:00 - use the slider to position the video.)  http://www.arcadiabio.com/celiacsafewheat.php

    • Dermatitis herpetiformis (DH) is an intensely itchy, blistering skin rash that affects 15 to 25 percent of people with celiac disease. The rash usually occurs on the elbows, knees, and buttocks. Most people with DH have no digestive symptoms of celiac disease.

    • People with celiac disease tend to have other diseases in which the immune system attacks the body’s healthy cells and tissues. The connection between celiac disease and these diseases may be genetic. They include:

      • type 1 diabetes
      • autoimmune thyroid disease
      • autoimmune liver disease
      • rheumatoid arthritis
      • Addison’s disease, a condition in which the glands that produce critical hormones are damaged
      • Sjögren’s syndrome, a condition in which the glands that produce tears and saliva are destroyed

    • Although lamb and pears are generally benign from an allergy perspective, I did not include rice in my "Tweet" on elimination diets, and some wondered why.  Rice itself is also gluten free, but some fear enriched rice sprayed with a vitamin coating could contain a gluten based grain.  You also want to be especially careful when eating out at a restaurant, as the preparation for Asian dishes may include soy sauces.  A very good article can be found here: http://gfkitchen.server101.com/rice.htm

    • Celiac Disease is frequently misdiagnosed as Irritable Bowel Syndrome, Inflammatory Bowel Disease, Crohn's disease, ulcerative colitis, proctitis, pancreatitis and even gall bladder disease, to name but a few related or similar digestive diseases.

    • Gluten is not used in the glue on envelopes and stamps made in this country.  That part is a myth, although we don't know about the manufacturing processes of other countries.  Here's the link to the Envelope Manufacturers Association (US) stating that envelopes do not contain gluten: http://www.envelope.org/page/6692/.  The association's website states that the glue is made from corn starch.  In the Fall 2007 issue of Gluten Free Living, Amy Ratner reported, "There are actually only a few envelope glue manufacturers in the United States. National Starch & Chemical, a New Jersey company, is one of the largest adhesive suppliers in the world. A company spokesperson says it makes its glue from corn, which is gluten free."  As for stamps, a Post Office spokesman told Ratner there's no gluten in stamp glue either. At any rate, the ingredients in stamp adhesives are much less of an issue, since the vast majority now have pressure adhesive glue and can be pressed onto your mail without the need to lick them.

    • IBS (Irritable Bowel Syndrome) sufferers talk about the effect of a gluten-free diet on their condition: http://www.irritable-bowel-syndrome.ws/gluten-free-diet.htm

    • A family history of "psychiatric problems" is more common in patients with celiac disease.  It is also believed that food allergy is a common cause of mental illness. Allergy to proteins from cow’s milk, hen’s eggs and wheat are the three most common problems. One idea is that antibodies generated by food proteins or peptides can attack the brain.  More: http://www.nutramed.com/celiac/celiacbrain.htm

    • Celiac Sprue Association starts national campaign to educate physicians on celiac disease.  You can arrange to have a copy of the educational materials sent to your physician by donating $70 to the association.  Details: http://www.csaceliacs.org/CSA-PEP.php

    • Alvine Pharmaceuticals is developing innovative therapeutic and diagnostic products for the treatment of celiac disease.  Alvine’s lead clinical product candidate - ALV003 - is an orally administered combination of two proteases engineered to digest gluten.  Initial technology created at Stanford and the Celiac Sprue Research Foundation: http://www.alvinepharma.com/index.asp?page=48

    • When 40 docs were challenged to test for celiac disease whenever classic symptoms were reported by their patients, the detection rates soared by 43 times the prior year's detection rate. Take charge of your health!  http://www.youtube.com/watch?v=IdxcBkQO1pY

    • Celiac Disease Linked to Dementia.  Gluten-Free Diet May Reverse Mental Decline in Patients.  Adults who develop the digestive condition known as celiac disease appear to be at increased risk for dementia, according to new research from the Mayo Clinic.  Link to WebMD article: http://www.webmd.com/news/20061013/celiac-disease-linked-dementia

    • Celiac disease manifestations can extend beyond the classic gastrointestinal problems, affecting any organ or body system. One of these manifestations—dental enamel defects—can help dentists and other health care providers identify people who may have celiac disease and refer them to a gastroenterologist. More: http://celiac.nih.gov/DentalEnamel.aspx

    • Celiac disease in Japan is virtually non-existent because the genes that cause the disease are not present in the population.  (see video in left column at minute mark 0:15:00)

    • Five excellent resources for children with celiac disease: http://bit.ly/4dTMpo
      (See also video lecture in left column beginning at minute marker 0:35:00 Note: use resize button under YouTube logo to view full-screen)

    • Digestive disorders cost Canadians $18 billion annually in health care and lost productivity: http://bit.ly/2MVYEl

    • FDA clears SQI's Multiplex platform. Product pipeline for 2010 includes autoimmune test panels for celiac disease: http://bit.ly/1KVLLk

    • Good Rule of Thumb for Allergy Sufferers: Try using the "Mono-Meal" concept talked about by Dr. Herbert M. Shelton, which means 1 food type per sitting: Why?  Different food types require different pH environments in the stomach, and consequently, different digestive juices are secreted for use in digesting different kinds of food substances. The inhibiting effect upon protein digestion of acids, sweets and fats makes it important to avoid combining these three types of foods at one meal.  Physicians recommend waiting anywhere from 2-4 hours before introducing another food type.  As always, each patient's diet needs are different, so consult your personal physician before making any dietary changes.  - Dr. Tatiana  (for a more detailed explanation <ctrl + click>: http://chetday.com/efdigest.html).

    • Shire to terminate collaboration with Alba Therapeutics on an experimental drug for celiac disease. http://tw0.us/4VT

    • Diagnosed with a chemical imbalance? Maybe nothing more than gluten at work.  Here's a link to the article: http://tw0.us/4P4

    • Sometimes irritable bowel syndrome (IBS) can present itself very similarly to celiac disase, as Elizabeth Hasselbeck found out: http://tinyurl.com/yzwxsqr.

    • The Specific Carbohydrate Diet (SCD) and how it relates to the management of Celiac Disease:  http://tw0.us/4KW

    • Celiac Disease, mood swings, and diet... Connecting the dots by hearing others discuss their problems. http://tw0.us/4KQ

    • A mother's tips on how to search for a celiac-friendly pediatrician. http://tw0.us/4JS

    • Australia: There's further confirmation today of the potential medical magic of an unlikely parasite - the hookworm: http://tw0.us/4Ed

    • Good summary of food additives and allergies.  I'm starting to wonder if the overall solution to gluten-free living should take food additives into account, in addition to the avoidance of wheat, barley, rye, and oats: http://tw0.us/4AB

    • More research needed: Is the growth in the number of celiac disease sufferers linked to genetically modified wheat? http://bit.ly/imgPd

    • Ethiopian scientist wins World Food Prize for sorghum. Sorghum is used for a range of gluten-free products.  Click here for story: http://bit.ly/77SLj

    • New England Journal of Medicine - Link between celiac, osteoporosis found.  Click here for story: http://bit.ly/16cRMs

    • Genetic Test for Celiac Disease Is Marketed Directly to Consumers Via Internet. Click here for the article: http://bit.ly/16Wl5K

    • Dietary Supplementation with Probiotics may be Beneficial in Celiac Disease. http://bit.lZ y/2YvVl (Available in my store under "Probiotics.")

    • Phadia to Launch Two New, Technologically-Advanced Diagnostic Tests. http://www.istockanalyst.com/article/viewiStockNews/articleid/3537361

    • The link between fertility, pregnancy, miscarriage & celiac disease grows - gluten-free diet creates positive results: http://bit.ly/vzKNH

    • USC researchers announced that they could identify and stratify risk based on HLA-DQ genotype process. More: http://bit.ly/pKXbT

    • Great government research source - PubMed. Putting in "Celiac Disease" in the search bar brought over 15K responses. More:  http://bit.ly/Jd4KI

    • Neurologist links migraine headaches to Celiac Disease.  More:  http://bit.ly/EIV6A

    • Vitamin A deficiency may be linked to celiac disease. Deficiency can be caused by low iron, excess alcohol... More: http://bit.ly/3JBhQo

    • Those with less severe symptoms of celiac disease may be at a higher risk of death [Updated]: http://bit.ly/IRjZD

    • More than 1/3 of schizophrenia patients showed gluten tolerance problems and some improvement with a gluten-free diet: http://bit.ly/4V3g9

    • Unconfirmed: Celiac Disease may impact twice as many women as men: http://tw0.us/59G http://bit.ly/x6Jhf

    • Maltese researchers find new celiac disease gene: http://bit.ly/dpjAH

    • Celiac Disease Poses Greater Mortality Risk Than Previously Thought: http://bit.ly/8jyx7

    • Health insurance company cancels policy for 17 year old stating Celiac Disease as a preexisting condition: http://bit.ly/uIOa0

     

     

     

     

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    Symptoms

    By Mayo Clinic staff

    There are no typical signs and symptoms of celiac disease. Most people with the disease have general complaints, such as:

    • Intermittent diarrhea
    • Abdominal pain
    • Bloating

    Sometimes people with celiac disease may have no gastrointestinal symptoms at all. Celiac disease symptoms can also mimic those of other conditions, such as irritable bowel syndrome, gastric ulcers, Crohn's disease, parasite infections, anemia, skin disorders or a nervous condition.

    Celiac disease may also present itself in less obvious ways, including:

    • Irritability or depression
    • Anemia
    • Stomach upset
    • Joint pain
    • Muscle cramps
    • Skin rash
    • Mouth sores
    • Dental and bone disorders (such as osteoporosis)
    • Tingling in the legs and feet (neuropathy)

    Some indications of malabsorption that may result from celiac disease include:

    • Weight loss
    • Diarrhea
    • Abdominal cramps, gas and bloating
    • General weakness and fatigue
    • Foul-smelling or grayish stools that may be fatty or oily
    • Stunted growth (in children)
    • Osteoporosis
    • Anemia

    Another gluten-related condition
    Dermatitis herpetiformis is an itchy, blistering skin disease that also stems from gluten intolerance. The rash usually occurs on the elbows, knees and buttocks. Dermatitis herpetiformis can cause significant intestinal damage identical to that of celiac disease. However, it may not produce noticeable digestive symptoms. This disease is treated with a gluten-free diet, in addition to medication to control the rash.

    When to see a doctor
    If you notice or experience any of the signs or symptoms common to celiac disease, see your doctor. If someone in your family is known to have celiac disease, you may need to be tested.

    Seek medical attention for a child who is pale, irritable, fails to grow, and who has a potbelly, flat buttocks and malodorous, bulky stools. Other conditions can cause these same signs and symptoms, so it's important to talk to your doctor before trying a gluten-free diet.

    For a more comprehensive review of Celiac Disease, click on this link: WebMD

    Another good discussion of the disease and it's symptoms is from the Celiac Sprue Association.


     
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